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Both a good reason not to wear a mask when it won’t do you any good, and also a reason why hydroxychloroquine (an alkaloid) also helps prevent cancer as well as COVID-19. They’re both metabolic disorders, the root problem being a shift of cellular metabolism away from efficient oxidative phosphorylation and into suboptimal glycolysis, resulting in an energy deficit, which causes the body to take adaptive measures.
marquee replied:
Interesting. Also, most cancer cells prefer glucose, but I don't understand the full picture thinking about it. In glycolysis there will be a build of pyruvate which can get converted to Acetyl-CoA in the mitochondria. Too much Acetyl-CoA though inhibits Pyruvate Kinase, the last stage in glycolysis. I guess the Acetyl-CoA could go into the Krebs' Cycle but then that requires oxygen for oxidative phosphorylation. Some of the Acetyl-CoA could just get stored as fat through the citrate shuttle converting to palmitic acid (16C fatty acid). I suspect the answer is more nuanced than we think, and some cancer cells behave differently to others. So, I dunno.
sandysmoothie replied:
A “good reason??” This card totally misconstrues his theories and then spells “Nobel” wrong for good measure. Please read up on his influence on modern cancer research. It has nothing to do with masks! Good lord!
ruth replied:
It’s all a bit more complicated, of course, than the picture I posted above, as lactic acid leaving the cell makes it internally more alkaline, and the lactic acid now outside the cell, allows damaging polyunsaturated fats to enter the cell, damaging the mitochondria and suppressing respiration. Cells should normally be internally acidic with an alkaline halo, constituting the charge separation of the membrane electrical bilayer and the capacitor-like/stored potential energy of the cell. Here’s a quote from Ray Peat, with his usual contrarian take on how starving the cancer cell of glucose isn’t a good way to get rid of it because you would starve yourself before you’d successfully starve the tumour... “The increased intracellular alkalinity and intracellular calcium that result from the combination of those factors increase the tendency of cells to be overstimulated, leading to aerobic glycolysis, the cancer metabolism. Improving any part of the system tends to increase carbon dioxide and decrease lactate, permitting differentiated functioning. There are many people currently recommending fish oil (or other highly unsaturated oils) for preventing or treating cancer, and it has become almost as common to recommend a sugar free diet, "because sugar feeds cancer." This is often, incorrectly, said to be the meaning of Warburg's demonstration that cancer cells have a respiratory defect that causes them to produce lactic acid from glucose even in the presence of oxygen. Cancer cells use glucose and the amino acid glutamine primarily for synthetic purposes, and use fats as their energy source;the growth stimulating effect of the "essential fatty acids" (Sueyoshi and Nagao, 1962a; Holley, et al., 1974) shows that depriving a tumor of those fats retards its growth. The great energetic inefficiency of the cancer metabolism, which causes it to produce a large amount of heat and to cause systemic stress, failure of immunity, and weight loss, is because it synthesizes fat from glucose and amino acids, and then oxidizes the fat as if it were diabetic. Estrogen, which is responsible for the fact that women burn fatty acids more easily than men, is centrally involved in this metabolic inefficiency. When a tissue is exposed to estrogen, within minutes it takes up water, and begins to synthesize fat, with a tendency to produce lactic acid at the same time. The alkalizing effect of lactic acid production is apparently what accounts for the uptake of water. Since it takes longer, at least 30 minutes, to produce a significant amount of new enzymes, these early changes are explained by the activation of existing enzymes by estrogen. The transhydrogenases, or the transhydrogenase function of the steroid dehydrogenases, which shift metabolic energy between glycolytic and oxidative systems, have been shown to explain these effects of estrogen, but the transhydrogenases can be activated by many stressors. The biological function of the transhydrogenases seems to be to allow cells to continue growth and repair processes in a hypoxic environment. Estrogen can start the process by creating new pathways for electrons, and will promote processes that are started by something else, and progesterone is estrogen's natural antagonist, terminating the process. Recently, a group at Johns Hopkins University (Le, et al., 2012) has been working out the implications of this ability to change the metabolism under hypoxia: Using an isotope-labeled amino acid, ". . . glutamine import and metabolism through the TCA cycle persisted under hypoxia, and glutamine contributed significantly to citrate carbons. Under glucose deprivation, glutamine-derived fumarate, malate, and citrate were significantly increased." The implication of this is that if the tumor isn't supplied with sugar, it will increase the rate at which it consumes the host's proteins.” http://raypeat.com/articles/articles/cancer-disorder-energy.shtml
ruth replied:
Yeah, the graphic isn’t best, I’ll agree - it was more of a conversation starter, and yes Warburg’s theories had nothing to do with mask wearing. But I stand by my statement that voluntarily doing anything to interfere with oxygen/CO2 balance for extended periods, when the Instructions on the mask box tell you it can’t prevent virus transmission, isn’t a great idea.
sandysmoothie replied:
You don't have to go contrarian to see his theories in action. Some cancer drugs approved by the FDA and in wide use starve cancer cells from their nutrients and are based on the Warburg effect. What he discovered is that cancer cells have plenty of oxygen, they just don't use it, they always go for the glucose. Cut off the glucose and they die. And you may believe that wearing a mask for an extended period limits your oxygen intake and they don't prevent virus transmission, but science would disagree in theory and practice. I am really hoping PowPing doesn't become yet another dumping ground for dumb ideas and misinformation on the internet!
ruth replied:
Wearing a mask for extended periods increases CO2 intake, which causes respiratory acidosis and forces kidneys to work much harder making bicarbonates and excreting acid. As the article stated, if you cut off glucose it will go after your other nutrients and you will suffer before the cancer does. I really don’t think this channel is going to be any use to you, as it is a place for people to explore ideas outside the mainstream ‘Overton window’, but you can continue to troll every comment if it pleases you.
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2 years ago
sandysmoothie replied:
Maybe better to update the channel description and name, as it doesn’t say any of that at all.